Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers' final pass 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory over the Indianapolis Colts on Monday night.
Purdy was 25 of 34 for 295 yards with one interception. Christian McCaffrey rushed 21 times for 117 yards and caught six passes for 29 yards and two scores. George Kittle had seven receptions for 115 yards and one TD.
The 49ers (11-4) won their fifth straight to stay in the chase for the NFC's top seed, one day after clinching a playoff spot by virtue of Detroit's loss to Pittsburgh. San Francisco also snapped a five-game losing streak in the series, beating Indy for the first time since Jim Mora's infamous "playoffs" rant in November 2001.